EEF1AKNMT Gene Summary [Human]
Predicted to enable methyltransferase activity. Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | EEF1AKNMT |
| Official Name | eEF1A lysine and N-terminal methyltransferase [Source:HGNC Symbol;Acc:HGNC:24248] |
| Ensembl ID | ENSG00000010165 |
| Bio databases IDs | |
| Aliases | eEF1A lysine and N-terminal methyltransferase, methyltransferase 13, eEF1A lysine and N-terminal methyltransferase, faint expression in normal tissues, aberrant overexpression in tumors |
| Synonyms | 5630401D24Rik, CGI-01, DFNB26, DFNB26M, DFNM1, EEF1AKNMT, feat, KIAA0859, methyltransferase 13, eEF1A lysine and N-terminal methyltransferase, methyltransferase 13, eEF1A N-terminus and K55, RGD1311526 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEF1AKNMT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- methyltransferase domain
- Spermine/spermidine synthase domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEF1AKNMT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein-lysine N-methyltransferase activity