Dapl1 Gene Summary [Mouse]
Predicted to enable ribosome binding activity; translation initiation factor binding activity; and translation repressor activity. Involved in negative regulation of CD8-positive, alpha-beta T cell activation. Acts upstream of or within cell population proliferation and gene expression. Is active in nucleus. Is expressed in 1-cell stage embryo; cap mesenchyme; eye; integumental system; and tongue epithelium. Orthologous to human DAPL1 (death associated protein like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dapl1 |
| Official Name | death associated protein-like 1 [Source:MGI Symbol;Acc:MGI:1923997] |
| Ensembl ID | ENSMUSG00000026989 |
| Bio databases IDs | |
| Aliases | death associated protein-like 1 |
| Synonyms | 2310032F03RIK, death associated protein-like 1, EEDA, RGD1309610 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dapl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death-associated protein
- translation repressor
- ribosome binding
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- insulin-dependent diabetes mellitus
- Alzheimer disease
- Parkinson disease
- angioedema
role in cell
- expression in
- quantity
- proliferation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dapl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of CD8-positive, alpha-beta T cell activation
- negative regulation of autophagy
- cellular response to amino acid starvation
- cell differentiation
- apoptotic signaling pathway
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding
- translation repressor activity
- translation initiation factor binding
- death domain binding