Fndc3b Gene Summary [Mouse]
Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fndc3b |
| Official Name | fibronectin type III domain containing 3B [Source:MGI Symbol;Acc:MGI:1919257] |
| Ensembl ID | ENSMUSG00000039286 |
| Bio databases IDs | |
| Aliases | fibronectin type III domain containing 3B |
| Synonyms | 1600019O04Rik, FAD104, fibronectin type III domain containing 3B, FLJ23399, mKIAA4164, PRO4979, RGD1311673, YVTM2421 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fndc3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FN3
- Fibronectin-III type domain
- protein binding
- Fibronectin type 3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- hypertrophic cardiomyopathy
- organismal death
- open-angle glaucoma
- keratoconus
- preeclampsia
- refractive error
- glaucoma
role in cell
- proliferation
- expression in
- phosphorylation in
- ubiquitination in
- migration
- binding in
- invasion by
- differentiation
- migration by
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fndc3b gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding