Pkp4 Gene Summary [Mouse]
Predicted to enable cadherin binding activity. Involved in cell-cell junction assembly. Located in postsynaptic density. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human PKP4 (plakophilin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkp4 |
| Official Name | plakophilin 4 [Source:MGI Symbol;Acc:MGI:109281] |
| Ensembl ID | ENSMUSG00000026991 |
| Bio databases IDs | |
| Aliases | plakophilin 4 |
| Synonyms | 5031422I09Rik, 9430019K17Rik, Armrp, p0071, Pkp4 predicted, Plakophilin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Armadillo/beta-catenin-like repeats
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insomnia
- pervasive developmental disorder
- metabolic syndrome X
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- papillary thyroid carcinoma
- papillary thyroid cancer
- abdominal aortic aneurysm
regulates
- GTPase
- ERBIN
role in cell
- outgrowth
- assembly
- cytokinesis in
- branching
- crizotinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell junction
- cytoskeleton
- Cytoplasm
- perinuclear region
- midbody
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytoplasmic face of plasma membrane
- lateral plasma membrane
- spindle pole
- central spindle
- mitotic spindle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell junction assembly
- cell-cell signaling
- regulation of cell adhesion
- positive regulation of GTPase activity
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- spindle pole
- plasma membrane
- internal side of plasma membrane
- cell-cell contact zone
- nucleus
- cornified envelope
- spindle midzone
- adherens junction
- cytoskeleton
- cell-cell junction
- perinuclear region of cytoplasm
- mitotic spindle
- cytoplasm
- cell junction
- desmosome
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding