Pgam1 Gene Summary [Mouse]
Enables phosphoglycerate mutase activity. Involved in gluconeogenesis. Located in myelin sheath. Is active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including PGAM1 (phosphoglycerate mutase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgam1 |
| Official Name | phosphoglycerate mutase 1 [Source:MGI Symbol;Acc:MGI:97552] |
| Ensembl ID | ENSMUSG00000011752 |
| Bio databases IDs | |
| Aliases | phosphoglycerate mutase 1 |
| Synonyms | 2310050F24Rik, HEL-S-35, PGAMA, PGAM-B, Pgmut, phosphoglycerate mutase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgam1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- bisphosphoglycerate phosphatase
- phosphoglycerate mutase
- phosphatase
- bisphosphoglycerate mutase
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
Pathways
Biological processes and signaling networks where the Pgam1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- tumorigenesis
- schizophrenia
- papillary thyroid carcinoma
- hepatocellular carcinoma
- papillary thyroid cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
role in cell
- invasion by
- migration
- proliferation
- formation
- formation in
- recruitment in
- gluconeogenesis in
- biosynthesis in
- double-stranded DNA break repair in
- homologous recombination repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgam1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- bisphosphoglycerate mutase activity
- phosphoglycerate mutase activity
- 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
- hydrolase activity