NUP35 Gene Summary [Human]

This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

Details

Type
Protein Coding
Official Symbol
NUP35
Official Name
nucleoporin 35 [Source:HGNC Symbol;Acc:HGNC:29797]
Ensembl ID
ENSG00000163002
Bio databases IDs NCBI: 129401 Ensembl: ENSG00000163002
Aliases nucleoporin 35, mitotic phosphoprotein 44
Synonyms 2310006I24RIK, 5330402E05Rik, AK009187, LOC129401, mitotic phosphoprotein 44, MP-44, NO44, NP44, nucleoporin 35, NUP53
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NUP35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA recognition motif (RRM) superfamily
  • protein binding
  • Nup53/35/40-type RNA recognition motif
  • identical protein binding
  • transporter

Pathways

Biological processes and signaling networks where the NUP35 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • COVID-19
  • glioma
  • glioma formation
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • interchromatin granule cluster fractions
  • intracellular membrane-bounded organelle
  • Plasma Membrane
  • cytosol
  • nuclear pores
  • nucleoplasm
  • nuclear rim
  • nuclear envelope
  • nuclear lamina

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human NUP35 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nucleocytoplasmic transport
  • nuclear pore organization
  • NLS-bearing substrate import into nucleus
  • mRNA transport

Cellular Component

Where in the cell the gene product is active
  • nuclear envelope
  • nuclear membrane
  • cytosol
  • plasma membrane
  • nucleoplasm
  • nuclear pore

Molecular Function

What the gene product does at the molecular level
  • nucleic acid binding
  • identical protein binding
  • protein binding
  • structural constituent of nuclear pore
  • phospholipid binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.