Zfp385b Gene Summary [Mouse]
Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in nucleus. Is expressed in central nervous system; heart; limb bud; and retina. Orthologous to human ZNF385B (zinc finger protein 385B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Zfp385b |
| Official Name | zinc finger protein 385B [Source:MGI Symbol;Acc:MGI:2444734] |
| Ensembl ID | ENSMUSG00000027016 |
| Bio databases IDs | |
| Aliases | zinc finger protein 385B |
| Synonyms | B830010L13RIK, C130013B13Rik, LOC102724263, Zfp385b, Zfp533, zinc finger protein 385B, ZNF533 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp385b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-finger double-stranded RNA-binding
- U1 zinc finger
- p53 binding
- zinc finger domain
- Zinc-finger of C2H2 type
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- urinary bladder disorder
- neuroblastoma
- neuroblastoma formation
- idiopathic scoliosis
- metabolic syndrome X
- gastritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Huntington disease
- dementia
role in cell
- expression in
- activation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp385b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction by p53 class mediator resulting in induction of apoptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- p53 binding
- zinc ion binding