Bmi1 Gene Summary [Mouse]
Enables promoter-specific chromatin binding activity and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PRC1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to several human genes including BMI1 (BMI1 proto-oncogene, polycomb ring finger). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmi1 |
| Official Name | Bmi1 polycomb ring finger oncogene [Source:MGI Symbol;Acc:MGI:88174] |
| Ensembl ID | ENSMUSG00000026739 |
| Bio databases IDs | |
| Aliases | Bmi1 polycomb ring finger oncogene |
| Synonyms | Bmi1 polycomb ring finger oncogene, BMI1 proto-oncogene, polycomb ring finger, FLVI2/BMI1, PCGF4, RNF51 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bmi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc finger of C3HC4-type, RING
- hththt domain
- chromatin binding
- protein domain specific binding
- enzyme regulator activity
- helix-turn-helix domain
- Ring finger domain
- protein binding
- enzyme activator activity
- PEST domain
- zinc ion binding
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- helix-loop-helix domain
- serine-proline rich domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Bmi1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal carcinomagenesis
- epithelial cancer
- epithelial neoplasia
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- replication in
- formation
- formation in
- phosphorylation in
- apoptosis
- expression in
- activation in
- binding in
- senescence
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polycomb group domain
- perichromatin region
- heterochromatin
- Cytoplasm
- cytosol
- nuclear foci
- chromosome
- interchromatin space
- nucleoplasm
- nuclear bodies
- nuclear speckles
- pericentric heterochromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bmi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- hemopoiesis
- rostrocaudal neural tube patterning
- apoptotic signaling pathway
- brain development
- positive regulation of immature T cell proliferation in thymus
- embryonic skeletal system morphogenesis
- segment specification
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of ubiquitin-protein ligase activity
- somatic stem cell division
- in utero embryonic development
- positive regulation of fibroblast proliferation
- humoral immune response
- regulation of gene expression
- positive regulation of B cell proliferation
- regulation of adaxial/abaxial pattern formation
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- PRC1 complex
- nuclear body
- ubiquitin ligase complex
- PcG protein complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin-protein ligase activator activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RING-like zinc finger domain binding