Nin Gene Summary [Mouse]
Enables microtubule minus-end binding activity. Acts upstream of or within several processes, including axonogenesis; microtubule cytoskeleton organization; and positive regulation of axonogenesis. Located in several cellular components, including axonal growth cone; dendrite; and microtubule cytoskeleton. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nin |
| Official Name | ninein [Source:MGI Symbol;Acc:MGI:105108] |
| Ensembl ID | ENSMUSG00000021068 |
| Bio databases IDs | |
| Aliases | ninein |
| Synonyms | 3110068G20RIK, AI385615, GSK3B-interacting, LOC100911256, mKIAA1565, NINEIN, SCKL7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Synaptonemal complex protein 1 (SCP-1)
- rad50
- helix-rich Mycoplasma protein
- protein binding
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- microtubule binding
- RecF/RecN/SMC N terminal domain
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- lupus nephritis
- schizophrenia
- ischemic stroke
- stroke
- refractive error
- Seckel syndrome 7
- male pattern hair loss
- organismal death
- infiltrating ductal breast carcinoma
role in cell
- formation
- number
- fragmentation
- abnormal morphology
- size
- localization
- misalignment in
- misalignment
- integrity
- CSN5i-3 sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- daughter centriole
- mother centriole
- axon component
- ciliary transition fiber
- subdistal appendage
- apical compartment
- Plasma Membrane
- basal bodies
- centrosome
- centriole
- centriolar appendages
- nucleoplasm
- nucleoli
- spindle pole
- cytoplasmic microtubule
- mitotic spindle
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome localization
- positive regulation of axonogenesis
- corticospinal tract morphogenesis
- centrosome-templated microtubule nucleation
- protein localization
- centriole-centriole cohesion
- collateral sprouting
- microtubule anchoring at centrosome
- corpus callosum morphogenesis
Cellular Component
Where in the cell the gene product is active
- spindle pole
- cytoplasmic microtubule
- nucleolus
- plasma membrane
- nucleoplasm
- dendrite
- pericentriolar material
- centrosome
- apical part of cell
- mitotic spindle
- axonal growth cone
- centriole
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- microtubule minus-end binding
- calcium ion binding
- kinase binding