Spta1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Acts upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in cuticular plate; membrane; and spectrin-associated cytoskeleton. Part of spectrin. Is expressed in liver; liver left lobe; liver right lobe; and utricle. Used to study hereditary spherocytosis type 1; hereditary spherocytosis type 3; and sickle cell anemia. Human ortholog(s) of this gene implicated in hereditary pyropoikilocytosis; hereditary spherocytosis; and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spta1 |
| Official Name | spectrin alpha, erythrocytic 1 [Source:MGI Symbol;Acc:MGI:98385] |
| Ensembl ID | ENSMUSG00000026532 |
| Bio databases IDs | |
| Aliases | spectrin alpha, erythrocytic 1 |
| Synonyms | alpha1 SPECTRIN, EL2, Erythroid Alpha-Spectrin, Erythroid α-Spectrin, ha, HPP, HS3, ihj, nmf4, Spectrin alpha 1, spectrin alpha, erythrocytic 1, spectrin, alpha, erythrocytic 1, Spectrin α 1, spectrin α, erythrocytic 1, spectrin, α, erythrocytic 1, sph, SPH3, Spna-1, SPTA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- actin filament binding
- EF-Hand
- Spectrin repeats
- chromosome segregation protein SMC, common bacterial type
- spectrin homology domain
- structural constituent of cytoskeleton
- Spectrin repeat
- EFh
- protein binding
- Ca2+ insensitive EF hand
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Spta1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- elliptocytosis type 2
- hemolytic anemia
- hereditary pyropoikilocytosis
- congenital hemolytic anemia
- autosomal recessive spherocytosis type 3
- hereditary spherocytosis
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- hemolysis
phenotypes
- increased heart rate
- increased startle reflex
- preweaning lethality complete penetrance
- shortened RR interval
- abnormal bone marrow cell number
- abnormal bone marrow morphology
- abnormal brain morphology
- abnormal cardiac thrombosis
- abnormal erythrocyte morphology
- abnormal erythrocyte osmotic lysis
- abnormal erythrocyte physiology
- abnormal erythropoiesis
- abnormal feces composition
- abnormal fertility/fecundity
- abnormal liver morphology
- abnormal lung morphology
- abnormal lymph node cell ratio
- abnormal maternal nurturing
- abnormal pulmonary alveolus wall morphology
- abnormal red blood cell deformability
- abnormal reticulocyte morphology
- abnormal skin pigmentation
- abnormal spleen morphology
- abnormal splenic cell ratio
- abnormal thrombosis
- alveolitis
- anemia
- anisocytosis
- anisopoikilocytosis
- cardiac hypertrophy
- decreased body size
- decreased cellular hemoglobin content
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased mean corpuscular hemoglobin concentration
- decreased mean corpuscular volume
- decreased spleen iron level
- decreased susceptibility to parasitic infection
- delayed hair appearance
- elliptocytosis
- enlarged heart
- enlarged liver
- enlarged liver sinusoidal spaces
- enlarged spleen
- erythroblastosis
- extramedullary hematopoiesis
- focal hepatic necrosis
- gallstones
- glomerulonephritis
- hemolysis
- hemolytic anemia
- hemosiderosis
- hypochromic microcytic anemia
- increased B cell number
- increased B cell proliferation
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgA level
- increased IgG level
- increased T cell number
- increased T cell proliferation
- increased bone marrow cell number
- increased circulating bilirubin level
- increased circulating iron level
- increased erythrocyte clearance
- increased erythrocyte osmotic fragility
- increased erythrocyte protoporphyrin level
- increased erythroid progenitor cell number
- increased kidney iron level
- increased leukocyte cell number
- increased liver iron level
- increased lymphocyte cell number
- increased mean corpuscular volume
- increased monocyte cell number
- increased neutrophil cell number
- increased nucleated erythrocyte cell number
- increased spleen weight
- increased susceptibility to bacterial infection
- infertility
- interstitial pneumonia
- jaundice
- liver degeneration
- liver vascular congestion
- low mean erythrocyte cell number
- lymph node hyperplasia
- macrocytosis
- microcytic anemia
- microcytosis
- myocardium necrosis
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- pallor
- poikilocytosis
- polychromatophilia
- postnatal lethality
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- premature death
- prenatal lethality incomplete penetrance
- preweaning lethality incomplete penetrance
- pulmonary fibrosis
- reduced female fertility
- renal necrosis
- renal tubular necrosis
- reticulocytosis
- schistocytosis
- spherocytosis
- tubular nephritis
- vasculature congestion
role in cell
- quantity
- proliferation
- organization
- hematopoiesis
- volume
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble fractions
- cortical cytoskeleton
- cytoskeleton
- cellular membrane
- actin cytoskeleton
- Nucleus
- vesicles
- Golgi Apparatus
- cytosol
- cytoplasmic face of plasma membrane
- cuticular plate
- multivesicular bodies
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spta1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- plasma membrane organization
- porphyrin-containing compound biosynthetic process
- actin filament capping
- hemopoiesis
- lymphocyte homeostasis
- actin filament organization
- positive regulation of T cell proliferation
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- actin cytoskeleton
- cytosol
- cell junction
- spectrin
- cuticular plate
- cell projection
- plasma membrane
- cortical actin cytoskeleton
- axon
- internal side of plasma membrane
- spectrin-associated cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- calcium ion binding
- structural constituent of cytoskeleton