Cenpe Gene Summary [Mouse]
Enables kinetochore binding activity and protein kinase binding activity. Involved in several processes, including attachment of spindle microtubules to kinetochore; positive regulation of protein kinase activity; and regulation of chromosome segregation. Acts upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Located in kinetochore. Part of outer kinetochore. Is expressed in dentate gyrus subgranular zone; testis; and thymus. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpe |
| Official Name | centromere protein E [Source:MGI Symbol;Acc:MGI:1098230] |
| Ensembl ID | ENSMUSG00000045328 |
| Bio databases IDs | |
| Aliases | centromere protein E |
| Synonyms | C530022J18, centromere protein E, KIF10, MCPH13, PPP1R61 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpe often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Synaptonemal complex protein 1 (SCP-1)
- Autophagy protein ATG17-like domain
- helix-rich Mycoplasma protein
- motor domain
- Putative golgin subfamily A member 2-like protein 5
- microtubule motor protein
- kinetochore binding domain
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- Mitotic checkpoint protein
- Crescentin protein
- microtubule binding domain
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- protein kinase binding
- Myosin and Kinesin motor domain
- rad50
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Protein of unknown function (DUF3584)
- Alpha helical coiled-coil rod protein (HCR)
- Kinesin motor, catalytic domain
- microtubule binding
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Kinesin motor domain
- Coiled-coil domain-containing protein 158
- Septation ring formation regulator, EzrA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- autosomal recessive primary microcephaly type 13
- ovarian neoplasm
- ovarian neoplasia
- epithelial cancer
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- testicular germ cell tumor
- germ cell neoplasia
regulates
- TP53
- BUB1B
role in cell
- expression in
- proliferation
- apoptosis
- binding
- cell death
- quantity
- formation
- accumulation
- misorientation
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- microtubules
- midbody
- Flemming body
- cytoplasmic bridges
- cytosol
- chromosome
- nuclear scaffolds
- kinetochore microtubule
- central spindle
- mitotic spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpe gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- mitotic spindle organization
- kinetochore assembly
- chromosome segregation
- mitotic chromosome movement towards spindle pole
- microtubule-based movement
- mitotic cell cycle
- cell division
- metaphase plate congression
- positive regulation of protein kinase activity
- mitotic metaphase plate congression
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- condensed chromosome, centromeric region
- kinetochore
- chromosome
- chromosome, centromeric region
- microtubule
- nucleus
- intercellular bridge
- spindle midzone
- mitotic spindle
- kinetochore microtubule
- intracellular membrane-bounded organelle
- membrane
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- kinetochore binding
- ATP binding
- microtubule motor activity
- protein binding
- microtubule binding