Slc23a2 Gene Summary [Mouse]
Enables L-ascorbate:sodium symporter activity and L-ascorbic acid transmembrane transporter activity. Involved in L-ascorbic acid transmembrane transport. Acts upstream of or within blood circulation. Located in basal plasma membrane and cytoplasm. Is expressed in several structures, including adrenal gland; central nervous system; liver; metanephros; and retina. Orthologous to human SLC23A2 (solute carrier family 23 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc23a2 |
| Official Name | solute carrier family 23 (nucleobase transporters), member 2 [Source:MGI Symbol;Acc:MGI:1859682] |
| Ensembl ID | ENSMUSG00000027340 |
| Bio databases IDs | |
| Aliases | solute carrier family 23 (nucleobase transporters), member 2 |
| Synonyms | hSVCT2, INTESTINE SPECIFIC SOLUTE CARRIER, KIAA0238, LOC102724905, mKIAA0238, NBTL1, NCBT2, SLC23A1, solute carrier family 23 member 2, solute carrier family 23 (nucleobase transporters), member 2, SVCT2, YSPL2, YSPL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc23a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Permease family
- uracil-xanthine permease
- xanthine permease
- L-ascorbate transporter
- protein binding
- L-ascorbate:sodium symporter
- transporter
Pathways
Biological processes and signaling networks where the Slc23a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- bleeding
- breast cancer
- respiratory failure
- cirrhosis
regulates
- collagen type i (family)
- argpyrimidine
- uric acid
- dehydroascorbic acid
- ascorbic acid
- CML advanced glycation end products
- pentosidine
- f2-isoprostanes
- dopamine
- epinephrine
role in cell
- abnormal morphology
- growth
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc23a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to ethanol
- sodium ion transport
- response to oxidative stress
- L-ascorbic acid transport
- blood circulation
- L-ascorbic acid metabolic process
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-ascorbate:sodium symporter activity
- L-ascorbic acid transporter activity
- transporter activity