Mcam Gene Summary [Mouse]
Predicted to enable laminin receptor activity. Predicted to be involved in angiogenesis and positive regulation of cell migration. Predicted to act upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; extraembryonic component; genitourinary system; gut; and nervous system. Orthologous to human MCAM (melanoma cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mcam |
| Official Name | melanoma cell adhesion molecule [Source:MGI Symbol;Acc:MGI:1933966] |
| Ensembl ID | ENSMUSG00000032135 |
| Bio databases IDs | |
| Aliases | melanoma cell adhesion molecule |
| Synonyms | 1-gicerin, CD146, CD149, HEMCAM, melanoma cell adhesion molecule, MELCAM, METCAM, MUC18, s-endo, s-gicerin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- CD19_double_Ig
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- cytosolic tail domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- organismal death
- melanoma
- melanoma cancer
- germ cell neoplasia
- psoriasis
role in cell
- expression in
- apoptosis
- growth
- phosphorylation in
- proliferation
- binding in
- formation
- adhesion
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- extracellular vesicles
- cytoskeleton
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- cell-cell contacts
- plasma membrane extracellular face
- GLUT4 vesicles
- apical cell-cell contacts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vascular wound healing
- angiogenesis
- glomerular filtration
- anatomical structure morphogenesis
- cell adhesion
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- focal adhesion
- external side of plasma membrane
- extracellular region
- plasma membrane