Sdcbp2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in cell population proliferation. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be active in cytoplasm and plasma membrane. Is expressed in embryo and pancreas epithelium. Orthologous to human SDCBP2 (syndecan binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdcbp2 |
| Official Name | syndecan binding protein (syntenin) 2 [Source:MGI Symbol;Acc:MGI:2385156] |
| Ensembl ID | ENSMUSG00000027456 |
| Bio databases IDs | |
| Aliases | syndecan binding protein (syntenin) 2 |
| Synonyms | SITAC, SITAC18, ST-2, syndecan binding protein 2, syndecan binding protein (syntenin) 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdcbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- phosphatidylinositol-4,5-bisphosphate binding
- protein homodimerization
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apical compartment
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdcbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- intracellular transport
- nervous system development
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- cytosol
- Golgi apparatus
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity