Tnp1 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Involved in positive regulation of protein processing and sperm DNA condensation. Acts upstream of or within spermatogenesis. Located in nucleus. Part of nucleosome. Is expressed in testis. Orthologous to human TNP1 (transition protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnp1 |
| Official Name | transition protein 1 [Source:MGI Symbol;Acc:MGI:98784] |
| Ensembl ID | ENSMUSG00000026182 |
| Bio databases IDs | |
| Aliases | transition protein 1 |
| Synonyms | Stp-1, TP1, Transition protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Nuclear transition protein 1
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthenozoospermia
role in cell
- formation
- morphology
- differentiation
- development
- abnormal morphology
- differentiation in
- remodeling
- cell movement
- disassembly
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid nucleus elongation
- spermatid development
- sperm chromatin decondensation
- spermatid nucleus differentiation
- sperm chromatin condensation
- nucleosome disassembly
- single strand break repair
- chromatin remodeling
- sperm motility
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
- positive regulation of protein processing
- sexual reproduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleosome
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding