Spag4 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; submandibular gland; and trachea. Orthologous to human SPAG4 (sperm associated antigen 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Spag4 |
| Official Name | sperm associated antigen 4 [Source:MGI Symbol;Acc:MGI:2444120] |
| Ensembl ID | ENSMUSG00000038180 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 4 |
| Synonyms | 1700041K21RIK, CT127, LOC100911109, mKIAA4118, MNCb-0953, sperm associated antigen 4, SUN4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sad1 / UNC-like C-terminal
- protein binding
- structural molecule
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear inner membrane
- motile cilium
- cytoskeleton
- cytoplasm
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein anchor
- structural molecule activity