Clstn1 Gene Summary [Mouse]
Predicted to enable X11-like protein binding activity; amyloid-beta binding activity; and kinesin binding activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; regulation of synapse maturation; and vesicle-mediated transport in synapse. Acts upstream of or within positive regulation of synapse assembly; positive regulation of synaptic transmission; and regulation of cell growth. Located in several cellular components, including cell surface; postsynaptic density; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic endosome. Is expressed in alimentary system; central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Orthologous to human CLSTN1 (calsyntenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clstn1 |
| Official Name | calsyntenin 1 [Source:MGI Symbol;Acc:MGI:1929895] |
| Ensembl ID | ENSMUSG00000039953 |
| Bio databases IDs | |
| Aliases | calsyntenin 1 |
| Synonyms | 1810034E21Rik, ALC-ALPHA, alcalpha2, ALC-α, calsyntenin 1, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clstn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- extracellular domain
- Calsyntenin C-terminal
- cytoplasmic domain
- intracellular domain
- Cadherin repeat-like domain
- X11-like protein binding
- protein binding
- KLC1-binding segment
- beta-amyloid binding
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- myeloproliferative neoplasm
- myeloproliferative disorder
- chronic periodontal disease
- primary myelofibrosis
- proliferative diabetic retinopathy
role in cell
- growth
- adhesion
- expression in
- formation
- binding in
- quantity
- abnormal morphology
- excitatory postsynaptic potential
- synaptic transmission in
- long-term potentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- interchromatin granule cluster fractions
- glutaminergic synapse
- cell surface
- Extracellular Space
- cellular membrane
- endosomes
- vesicles
- postsynaptic membrane
- synaptic membrane
- synapse
- recycling endosomes
- early endosomes
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clstn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- regulation of cell growth
- positive regulation of synaptic transmission
- cell adhesion
- homophilic cell adhesion
- positive regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- nucleus
- postsynaptic membrane
- Golgi membrane
- extracellular region
- neuron projection
- cell surface
Molecular Function
What the gene product does at the molecular level
- X11-like protein binding
- protein binding
- calcium ion binding
- kinesin binding
- beta-amyloid binding