Fam210b Gene Summary [Mouse]
Acts upstream of or within several processes, including erythrocyte differentiation; reactive oxygen species metabolic process; and spleen development. Is active in mitochondrion. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Used to study systemic lupus erythematosus. Orthologous to human FAM210B (family with sequence similarity 210 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam210b |
| Official Name | family with sequence similarity 210, member B [Source:MGI Symbol;Acc:MGI:1914267] |
| Ensembl ID | ENSMUSG00000027495 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 210, member B |
| Synonyms | 2010011I20Rik, 5A3, C20orf108, dJ1167H4.1, family with sequence similarity 210 member B, family with sequence similarity 210, member B, RGD1311378 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam210b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAM210A/B-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- lung adenocarcinoma formation
- EGFR mutation positive adenocarcinoma of the lung
- EGFR mutation positive non-small cell lung cancer
- EGFR expression positive non-squamous non-small cell lung cancer
regulates
- reactive oxygen species
- Immunoglobulin
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam210b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to estradiol stimulus
- positive regulation of erythrocyte differentiation
- erythrocyte maturation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding