F2rl1 Gene Summary [Mouse]
Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and proteinase-activated receptor activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and regulation of protein secretion. Located in pseudopodium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skin. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy. Orthologous to human F2RL1 (F2R like trypsin receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F2rl1 |
| Official Name | coagulation factor II (thrombin) receptor-like 1 [Source:MGI Symbol;Acc:MGI:101910] |
| Ensembl ID | ENSMUSG00000021678 |
| Bio databases IDs | |
| Aliases | coagulation factor II (thrombin) receptor-like 1 |
| Synonyms | F2R like trypsin receptor 1, Gpcr11, GPR11, g α q coupled proteinase activated receptor 2, PAR-2, PROTEINASE-ACTIVATED receptor-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse F2rl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- tethered ligand domain
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- signaling receptor activity
- binding protein
- protease binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
- proteinase activated receptor
Pathways
Biological processes and signaling networks where the F2rl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gα12/13 Signaling
- p70S6K Signaling
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Tissue Factor in Cancer
- SPINK1 Pancreatic Cancer Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- neoplasia
- weight gain
- pain
- metastasis
- airway hyperresponsiveness
- atopic dermatitis
- thermal hyperalgesia
- obesity
- reperfusion injury
role in cell
- expression in
- activation in
- replication in
- phosphorylation in
- cell death
- apoptosis
- production in
- cellular infiltration by
- cell viability
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- vesicles
- Golgi Apparatus
- apical membrane
- basolateral membrane
- early endosomes
- secretory vesicles
- tertiary granules
- brush border
- pseudopodia
- cell membrane leading edge
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse F2rl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of blood coagulation
- positive regulation of renin secretion into blood stream
- T cell activation involved in immune response
- positive regulation of GTPase activity
- inflammatory response
- positive regulation of interferon-gamma production
- defense response to virus
- positive regulation of neutrophil mediated killing of gram-negative bacterium
- positive regulation of chemokine production
- positive regulation of toll-like receptor 3 signaling pathway
- negative regulation of toll-like receptor 3 signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of toll-like receptor 4 signaling pathway
- negative regulation of chemokine production
- positive regulation of pseudopodium assembly
- positive regulation of positive chemotaxis
- positive regulation of leukocyte chemotaxis
- positive regulation of eosinophil degranulation
- cell-cell junction maintenance
- positive regulation of cytokine production involved in immune response
- positive regulation of interleukin-8 production
- positive regulation of toll-like receptor 2 signaling pathway
- positive regulation of interleukin-6 production
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- neutrophil activation
- positive regulation of phagocytosis, engulfment
- positive regulation of Rho protein signal transduction
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of insulin secretion
- vasodilation
- blood coagulation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of glomerular filtration
- leukocyte proliferation
- mature dendritic cell differentiation
- phospholipase C-activating G-protein coupled receptor signaling pathway
- negative regulation of JNK cascade
- establishment of endothelial barrier
- regulation of JNK cascade
- elevation of cytosolic calcium ion concentration
- thrombin receptor signaling pathway
- positive regulation of actin filament depolymerization
- innate immune response
- positive regulation of JNK cascade
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of ERK1 and ERK2 cascade
- leukocyte migration
- regulation of chemokine (C-X-C motif) ligand 2 production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
- positive regulation of superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- early endosome
- Golgi apparatus
- pseudopodium
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- thrombin receptor activity
- protein binding
- G-protein beta-subunit binding
- G-protein alpha-subunit binding
- signaling receptor activity
- protease binding
- receptor binding