Mboat7 Gene Summary [Mouse]
Enables O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling and regulation of triglyceride metabolic process. Acts upstream of or within layer formation in cerebral cortex; phosphatidylinositol metabolic process; and ventricular system development. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mboat7 |
| Official Name | membrane bound O-acyltransferase domain containing 7 [Source:MGI Symbol;Acc:MGI:1924832] |
| Ensembl ID | ENSMUSG00000035596 |
| Bio databases IDs | |
| Aliases | membrane bound O-acyltransferase domain containing 7 |
| Synonyms | 5730589L02Rik, BB1, hMBOA-7, LENG4, LOC100909580, LPIAT, LPIAT1, LPLAT, LPLAT11, LPLAT 7, LRC4, MBOA7, Mboat7l1, membrane bound O-acyltransferase domain containing 7, m-mboa-7, MRT57, OACT7, RGD1306945 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mboat7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- O-acyltransferase
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic fatty liver disease
- hepatic steatosis
- autosomal recessive mental retardation type 57
- organismal death
- hypoplasia
- hereditary disorder
- KRAS G12X activating mutation positive non-small cell lung cancer
- tumorigenesis
- hydrocephalus
role in cell
- production in
- proliferation
- apoptosis
- migration
- abnormal morphology
- differentiation
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mboat7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- layer formation in cerebral cortex
- phosphatidylcholine acyl-chain remodeling
- phosphatidylinositol biosynthetic process
- phosphatidylinositol acyl-chain remodeling
- regulation of triglyceride metabolic process
- lipid modification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- protein binding
- O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity