Vamp3 Gene Summary [Mouse]
Predicted to enable SNAP receptor activity and syntaxin-1 binding activity. Involved in SNARE complex assembly; positive regulation of receptor recycling; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including Golgi to plasma membrane protein transport; calcium-ion regulated exocytosis; and cellular response to type II interferon. Located in several cellular components, including cell surface; cytoplasmic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including adrenal gland; brain; and gonad. Orthologous to human VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vamp3 |
| Official Name | vesicle-associated membrane protein 3 [Source:MGI Symbol;Acc:MGI:1321389] |
| Ensembl ID | ENSMUSG00000028955 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein 3 |
| Synonyms | CEB, cellubrevin, D130027G05Rik, vesicle-associated membrane protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vamp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- cytoplasmic domain
- syntaxin-1 binding
- coiled-coil domain
- protein binding
- cytosolic tail domain
- SNARE motif
Pathways
Biological processes and signaling networks where the Vamp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- severe acute respiratory syndrome
- renal cell cancer
- liver cancer
- hepatocellular carcinoma
- organismal death
- renal cell carcinoma
role in cell
- cell death
- expression in
- apoptosis
- proliferation
- migration
- phosphorylation in
- glycolysis in
- fusion
- function
- secretion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- intracellular membrane fractions
- raft fractions
- low-density microsomal fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- intracellular compartment
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- pericentriolar regions
- cellular membrane
- Nucleus
- vacuole
- endosomes
- vesicles
- cytosol
- apical cell surfaces
- cytoplasmic face of plasma membrane
- apical membrane
- basolateral membrane
- trans Golgi network
- endosomal compartment
- endosomal membrane
- alpha granule membranes
- recycling endosomes
- early endosomes
- late endosomes
- transport vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- secretory granules
- clathrin-coated vesicles
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vamp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- macromolecular complex assembly
- SNARE complex assembly
- Golgi to plasma membrane protein transport
- retrograde transport, endosome to Golgi
- exocytosis
- vesicle-mediated transport
- mucus secretion
- vesicle fusion
- positive regulation of receptor recycling
- vesicle docking involved in exocytosis
- substrate adhesion-dependent cell spreading
- positive regulation of immunoglobulin production
- calcium ion-dependent exocytosis
- cellular response to interferon-gamma
Cellular Component
Where in the cell the gene product is active
- secretory granule
- synapse
- neuron projection
- plasma membrane
- cell surface
- early endosome membrane
- perinuclear region of cytoplasm
- clathrin-coated endocytic vesicle membrane
- intracellular membrane-bounded organelle
- membrane
- cytosol
- SNARE complex
- phagocytic vesicle membrane
- recycling endosome
- recycling endosome membrane
- transport vesicle
- clathrin-coated vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin-1 binding
- SNAP receptor activity