Plpp6 Gene Summary [Mouse]
Predicted to enable isoprenoid diphosphate phosphatase activity and phosphatase activity. Predicted to be involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Predicted to be located in endoplasmic reticulum membrane and nuclear membrane. Predicted to be active in membrane. Is expressed in several structures, including eye; genitourinary system; gut; nervous system; and skin. Orthologous to human PLPP6 (phospholipid phosphatase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plpp6 |
| Official Name | phospholipid phosphatase 6 [Source:MGI Symbol;Acc:MGI:1921661] |
| Ensembl ID | ENSMUSG00000040105 |
| Bio databases IDs | |
| Aliases | phospholipid phosphatase 6 |
| Synonyms | 4932443D16Rik, bA6J24.6, LPRP-B, PA-PSP, PDP1, phospholipid phosphatase 6, PPAPDC2, PSDP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plpp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acid phosphatase homologues
- lipid phosphatase
- PAP2 superfamily
- sphingosine-1-phosphate phosphatase
- pyrophosphatase
- phosphatidate phosphatase
- phosphatase
- hydrolase
- protein binding
- PAP2_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- superoxide
- cholesterol
- phospholipid
- farnesyl pyrophosphate
- terpenoid
- geranyl pyrophosphate
role in cell
- activation
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plpp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid dephosphorylation
- innate immune response
- geranyl diphosphate metabolic process
- cholesterol biosynthetic process
- protein prenylation
- farnesyl diphosphate catabolic process
- isoprenoid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- nuclear inner membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- protein binding
- lysophosphatidic acid phosphatase activity
- sphingosine-1-phosphate phosphatase activity
- lyase activity
- lipid phosphatase activity
- hydrolase activity