PHACTR3 Gene Summary [Human]

This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Details

Type
Protein Coding
Official Symbol
PHACTR3
Official Name
phosphatase and actin regulator 3 [Source:HGNC Symbol;Acc:HGNC:15833]
Ensembl ID
ENSG00000087495
Bio databases IDs NCBI: 116154 Ensembl: ENSG00000087495
Aliases phosphatase and actin regulator 3, protein phosphatase 1, regulatory subunit 123
Synonyms 1500003N10RIK, 4930415A02RIK, C20ORF101, H17739, mKIAA4224, phosphatase and actin regulator 3, PPP1R123, SCAPIN1, SCAPININ
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHACTR3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase inhibitor activity
  • actin-binding domain
  • RPEL repeat
  • actin binding
  • protein binding
  • phosphorylation site

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • dementia
  • pediatric inflammatory bowel disease
  • schizophrenia
  • idiopathic pulmonary fibrosis
  • refractive error
  • TCF3-PBX1 fusion positive acute lymphoblastic leukemia
regulated by
regulates
role in cell
  • elongation in
  • elongation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • intermediate filaments
  • nucleoplasm
  • nuclear scaffolds
  • axons

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PHACTR3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • actin cytoskeleton organization

Cellular Component

Where in the cell the gene product is active
  • nuclear matrix
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein phosphatase inhibitor activity
  • protein binding
  • actin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.