G3bp1 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | G3bp1 |
| Official Name | GTPase activating protein (SH3 domain) binding protein 1 [Source:MGI Symbol;Acc:MGI:1351465] |
| Ensembl ID | ENSMUSG00000018583 |
| Bio databases IDs | |
| Aliases | GTPase activating protein (SH3 domain) binding protein 1 |
| Synonyms | AI849976, B430204O07, C87777, G3BP, G3BP stress granule assembly factor 1, HDH-VIII, mKIAA4115, Ras gtpase activating protein sh3 domain binding, Ras gtpase activating sh3 domain binding, RGD1310666, RP23-336J1.4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G3bp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- helicase
- protein binding activity, bridging
- enzyme
- protein binding
- DNA dependent ATPase
- RNA helicase
- RNA dependent ATPase
- DNA helicase
- NTF2_like
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- breast cancer
- Alzheimer disease
- epithelial basal cell carcinoma
- endometrial cancer
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- Waldenström macroglobulinemia
role in cell
- proliferation
- binding in
- expression in
- downregulation in
- migration
- phosphorylation in
- growth
- upregulation in
- apoptosis
- transmembrane potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- polyribosome fractions
- detergent resistant lipid raft fraction
- Cytoplasm
- cellular membrane
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G3bp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- stress granule assembly
- innate immune response
- positive regulation of type I interferon production
- DNA duplex unwinding
- defense response to virus
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- focal adhesion
- cytoplasm
- cytosol
- perikaryon
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- DNA helicase activity
- protein binding
- RNA binding
- RNA helicase activity
- endonuclease activity
- ribosomal small subunit binding
- mRNA binding
- DNA/RNA helicase activity