Dr1 Gene Summary [Mouse]
Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in nucleus. Part of ATAC complex. Is expressed in central nervous system; early conceptus; genitourinary system; limb mesenchyme; and neural retina. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dr1 |
| Official Name | down-regulator of transcription 1 [Source:MGI Symbol;Acc:MGI:1100515] |
| Ensembl ID | ENSMUSG00000029265 |
| Bio databases IDs | |
| Aliases | down-regulator of transcription 1 |
| Synonyms | 1700121L09Rik, down-regulator of transcription 1, DR1L, LOC100910207, NC2, NC2B, NC2-BETA, NC2-β, NCB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- glutamine-alanine rich domain
- transcription regulator
- TBP binding domain
- protein binding
- general RNA polymerase II transcription factor
- TATA-binding protein binding
Pathways
Biological processes and signaling networks where the Dr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- inflammatory bowel disease
- Crohn disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- apoptosis
- assembly
- cell cycle progression
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- RNA polymerase II transcriptional preinitiation complex assembly
- regulation of embryonic development
- regulation of tubulin deacetylation
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- negative cofactor 2 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- TBP-class protein binding