Tm4sf1 Gene Summary [Mouse]
Acts upstream of or within blastocyst formation. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in cardiovascular system; early conceptus; floor plate; pancreas; and secondary oocyte. Orthologous to human TM4SF1 (transmembrane 4 L six family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tm4sf1 |
| Official Name | transmembrane 4 superfamily member 1 [Source:MGI Symbol;Acc:MGI:104678] |
| Ensembl ID | ENSMUSG00000027800 |
| Bio databases IDs | |
| Aliases | transmembrane 4 superfamily member 1 |
| Synonyms | H-L6, L6, M3S1, MGC:14656, TAAL6, transmembrane 4 L six family member 1, transmembrane 4 superfamily member 1, TUMOR ASSOCIATED ANTIGEN 6, tumour ASSOCIATED ANTIGEN 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tm4sf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L6 membrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal squamous cell carcinoma
- metastasis
- oral squamous cell carcinoma
- organismal death
- squamous cell cancer of the oral cavity
- esophageal squamous cell cancer
- leiomyomatosis
- uterine leiomyoma
- cholangiocarcinoma
regulates
- AKT
- cisplatin
role in cell
- formation
- formation in
- apoptosis
- activation in
- quantity
- proliferation
- invasion by
- growth
- cisplatin sensitivity
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- perinuclear vesicles
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tm4sf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blastocyst formation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding