Itgb5 Gene Summary [Mouse]
Enables integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge and focal adhesion. Part of integrin alphav-beta5 complex. Is active in glutamatergic synapse and synaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgb5 |
| Official Name | integrin beta 5 [Source:MGI Symbol;Acc:MGI:96614] |
| Ensembl ID | ENSMUSG00000022817 |
| Bio databases IDs | |
| Aliases | integrin beta 5 |
| Synonyms | [b]-5, [b]5A, [b]5B, beta-5, Beta5 integrin, ESTM23, integrin beta 5, Integrin Beta X, integrin subunit beta 5, integrin subunit β 5, Integrin β 5, Integrin β X, RGD1563276, β-5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itgb5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin beta chain VWA domain
- Integrin plexin domain
- protein binding
- receptor binding
- Integrin beta subunits (N-terminal portion of extracellular region)
- Integrin beta tail domain
- Integrin beta cytoplasmic domain
- PAK4 binding membrane proximal domain
- cytoplasmic domain
- vWFA
- integrin binding
- cytosolic tail domain
- Integrin beta epidermal growth factor like domain 1
Pathways
Biological processes and signaling networks where the Itgb5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Integrin Signaling
- Macropinocytosis Signaling
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- liver cancer
- non-insulin-dependent diabetes mellitus
- hypertension
- lung squamous cell carcinoma
- squamous cell lung cancer
- dextran sodium sulfate-induced colitis
- tumor
- peritoneal endometriosis
role in cell
- expression in
- growth
- proliferation
- phosphorylation in
- activation in
- colony formation
- number
- migration
- cell death
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- focal adhesions
- synaptic membrane
- cell membrane leading edge
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itgb5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cell-matrix adhesion
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- epithelial cell-cell adhesion
- transforming growth factor beta receptor signaling pathway
- endodermal cell differentiation
- stress fiber assembly
- wound healing, spreading of epidermal cells
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- alphav-beta5 integrin complex
- phagocytic vesicle
- receptor complex
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- viral receptor activity
- integrin binding