TM4SF1 Gene Summary [Human]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TM4SF1 |
| Official Name | transmembrane 4 L six family member 1 [Source:HGNC Symbol;Acc:HGNC:11853] |
| Ensembl ID | ENSG00000169908 |
| Bio databases IDs | |
| Aliases | transmembrane 4 L six family member 1 |
| Synonyms | H-L6, L6, M3S1, MGC:14656, TAAL6, transmembrane 4 L six family member 1, transmembrane 4 superfamily member 1, TUMOR ASSOCIATED ANTIGEN 6, tumour ASSOCIATED ANTIGEN 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TM4SF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L6 membrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal squamous cell carcinoma
- metastasis
- oral squamous cell carcinoma
- organismal death
- squamous cell cancer of the oral cavity
- esophageal squamous cell cancer
- leiomyomatosis
- uterine leiomyoma
- cholangiocarcinoma
regulates
- AKT
- cisplatin
role in cell
- formation
- formation in
- apoptosis
- activation in
- quantity
- proliferation
- invasion by
- growth
- cisplatin sensitivity
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- cellular membrane
- perinuclear vesicles
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TM4SF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blastocyst formation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding