Tshb Gene Summary [Mouse]
Predicted to enable hormone activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 4 and hypothyroidism. Orthologous to human TSHB (thyroid stimulating hormone subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tshb |
| Official Name | thyroid stimulating hormone, beta subunit [Source:MGI Symbol;Acc:MGI:98848] |
| Ensembl ID | ENSMUSG00000027857 |
| Bio databases IDs | |
| Aliases | thyroid stimulating hormone, beta subunit |
| Synonyms | thyroid stimulating hormone, beta subunit, thyroid stimulating hormone subunit beta, thyroid stimulating hormone subunit β, thyroid stimulating hormone, β subunit, Tsh, TSH-BETA, TSH-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tshb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- hormone
Pathways
Biological processes and signaling networks where the Tshb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nongoitrous congenital hypothyroidism type 4
- secondary hypothyroidism
- pituitary gland adenoma
- adenoma formation
- head and neck neuroendocrine neoplasia
role in cell
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tshb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- G-protein coupled receptor signaling pathway
- response to calcium ion
- cell-cell signaling
- anatomical structure morphogenesis
- response to vitamin A
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity