Ubxn7 Gene Summary [Mouse]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ubxn7 |
| Official Name | UBX domain protein 7 [Source:MGI Symbol;Acc:MGI:2146388] |
| Ensembl ID | ENSMUSG00000053774 |
| Bio databases IDs | |
| Aliases | UBX domain protein 7 |
| Synonyms | A630090P18, KIAA0794, mKIAA0794, RGD1306346, UBXD7, UBX domain protein 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubxn7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ubiquitin protein ligase binding
- UBA-like domain
- Thioredoxin-like
- Ubl1_cv_Nsp3_N-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- ubiquitin binding
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- albuminuria
- schizophrenia
- tubulo-interstitial fibrosis
- metabolic syndrome X
role in cell
- expression in
- cellular infiltration by
- degradation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubxn7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- Cdc48p-Npl4p-Ufd1p AAA ATPase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- ubiquitin binding