Micall2 Gene Summary [Mouse]
Enables cytoskeletal protein binding activity and small GTPase binding activity. Involved in several processes, including Rab protein signal transduction; actin filament polymerization; and bicellular tight junction assembly. Acts upstream of or within endocytic recycling. Located in several cellular components, including actin filament bundle; bicellular tight junction; and recycling endosome. Colocalizes with stress fiber. Is expressed in several structures, including chondrocranium; liver lobe; medulla oblongata basal plate; submandibular gland primordium; and vibrissa. Orthologous to human MICALL2 (MICAL like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Micall2 |
| Official Name | MICAL-like 2 [Source:MGI Symbol;Acc:MGI:2444818] |
| Ensembl ID | ENSMUSG00000036718 |
| Bio databases IDs | |
| Aliases | MICAL-like 2 |
| Synonyms | A930021H16Rik, FLJ34667, JRAB, mFLJ00139, MICAL-like 2, RGD1307875 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Micall2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Calponin homology domain
- cytoskeletal protein binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- Bivalent Mical/EHBP Rab binding domain
- enzyme binding
- calponin homology (CH) domain superfamily
- central domain
- coiled-coil domain
- protein binding
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastroesophageal reflux
- Joubert syndrome type 1
- organismal death
- endometrioid cancer
- clear cell ovarian cancer
- serous ovarian cancer
- mucinous ovarian cancer
role in cell
- expression in
- degradation in
- phosphorylation in
- invasion by
- formation
- binding in
- outgrowth
- polymerization
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- perinuclear region
- actin cytoskeleton
- Plasma Membrane
- intercellular junctions
- neurites
- recycling endosomes
- actin stress fibers
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Micall2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- actin filament polymerization
- tight junction assembly
- substrate adhesion-dependent cell spreading
- actin cytoskeleton organization
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- tight junction
- cell-cell junction
- stress fiber
- actin filament bundle
- cytosol
- recycling endosome
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actinin binding
- metal ion binding
- small GTPase binding
- filamin binding