Gar1 Gene Summary [Mouse]
Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis and telomere maintenance via telomerase. Predicted to be located in dense fibrillar component; fibrillar center; and nucleoplasm. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gar1 |
| Official Name | GAR1 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1930948] |
| Ensembl ID | ENSMUSG00000028010 |
| Bio databases IDs | |
| Aliases | GAR1 ribonucleoprotein |
| Synonyms | C430047J18Rik, GAR1 ribonucleoprotein, NOLA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- Gar1/Naf1 RNA binding region
- snoRNA binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- fibrillar center
- gems
- dense fibrillar component
- nucleoplasm
- nucleoli
- Cajal bodies
- telomeres
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomere maintenance via telomerase
- snoRNA guided rRNA pseudouridine synthesis
Cellular Component
Where in the cell the gene product is active
- box H/ACA snoRNP complex
- chromosome, telomeric region
- box H/ACA scaRNP complex
- telomerase holoenzyme complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- telomeric RNA binding
- box H/ACA snoRNA binding