Chmp4c Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including proteolysis involved in protein catabolic process; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including Flemming body; bounding membrane of organelle; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in cytoplasmic side of plasma membrane and multivesicular body. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; lung; and lymph node. Orthologous to human CHMP4C (charged multivesicular body protein 4C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp4c |
| Official Name | charged multivesicular body protein 4C [Source:MGI Symbol;Acc:MGI:1913621] |
| Ensembl ID | ENSMUSG00000027536 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 4C |
| Synonyms | 2010012P02Rik, 2210015K02Rik, 2310010I16Rik, charged multivesicular body protein 4C, Shax3, SNF7-3, VPS32C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTZ00464
- protein homodimerization
- protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp4c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian carcinoma
- hearing loss
- age-related hearing loss
- heart disease
- epithelial ovarian cancer
- organismal death
- periodontitis
- cardiac hypertrophy
role in cell
- autophagy by
- activation in
- quantity
- mitosis
- sorting
- fusion
- assembly
- abscission
- hypertrophy
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endosomes
- vesicles
- midbody
- Flemming body
- cytosol
- lysosome membrane
- nuclear pores
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp4c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- nucleus organization
- abscission
- membrane budding
- regulation of centrosome duplication
- non-lytic virus budding from plasma membrane
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- autophagy
- multivesicular body sorting pathway
- negative regulation of cytokinesis
- nuclear envelope reassembly
- mitotic metaphase plate congression
- macroautophagy
- late endosome to vacuole transport via multivesicular body sorting pathway
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- plasma membrane
- lysosomal membrane
- autophagic vacuole membrane
- nuclear pore
- internal side of plasma membrane
- kinetochore microtubule
- cytosol
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity