Il13ra2 Gene Summary [Mouse]
This gene encodes a receptor protein that binds to interleukin 13 (IL-13) with very high affinity. The encoded protein acts as a decoy receptor, and does not elicit any signal upon the binding of IL-13. Mice lacking the encoded protein exhibit increased levels of serum immunoglobulins, immune-dependent production of interferon gamma and, increased bone marrow macrophage progenitor frequency. Macrophages lacking the encoded protein release less nitric oxide and IL-12 in response to lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Il13ra2 |
| Official Name | interleukin 13 receptor, alpha 2 [Source:MGI Symbol;Acc:MGI:1277954] |
| Ensembl ID | ENSMUSG00000031289 |
| Bio databases IDs | |
| Aliases | interleukin 13 receptor, alpha 2 |
| Synonyms | CD213A2, CT19, IL13BP, IL-13R, IL-13R-alpha-2, IL-13R-α-2, interleukin 13 receptor, alpha 2, interleukin 13 receptor subunit alpha 2, interleukin 13 receptor subunit α 2, interleukin 13 receptor, α 2, LOC100361488 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il13ra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- transmembrane domain
- extracellular ligand binding domain
- intracellular domain
- protein binding
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il13ra2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- colorectal cancer
- glioblastoma
- colitis
- irritation
- airway hyperresponsiveness
- fibrosis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- proliferation
- expression in
- differentiation
- growth
- phosphorylation in
- number
- migration
- function
- invasion by
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il13ra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- negative regulation of immunoglobulin production
- immunoglobulin mediated immune response
- negative regulation of mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- receptor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine binding
- cytokine receptor activity