Mrpl12 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial transcription; positive regulation of DNA-templated transcription; and translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 45. Orthologous to human MRPL12 (mitochondrial ribosomal protein L12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrpl12 |
| Official Name | mitochondrial ribosomal protein L12 [Source:MGI Symbol;Acc:MGI:1926273] |
| Ensembl ID | ENSMUSG00000039640 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosomal protein L12 |
| Synonyms | 0610034O11Rik, 1500031N16Rik, 5c5-2, bL12m, L12mt, mitochondrial ribosomal protein L12, MRP-L31/34, MRPL7, MRPL7/L12, ribosomal protein, mitochondrial, L7, RPM12, RPML12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrpl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein binding
- ribosomal protein L7/L12
- Ribosomal_L7_L12
- Ribosomal protein L7/L12 dimerization domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- combined oxidative phosphorylation deficiency 45
role in cell
- expression in
- transcription in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrpl12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from mitochondrial promoter
- positive regulation of transcription, DNA-dependent
- mitochondrial translation
- translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- mRNA binding