Chd1l Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; nucleosome binding activity; and poly-ADP-D-ribose modification-dependent protein binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus and site of double-strand break. Is expressed in genitourinary system and liver. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chd1l |
| Official Name | chromodomain helicase DNA binding protein 1-like [Source:MGI Symbol;Acc:MGI:1915308] |
| Ensembl ID | ENSMUSG00000028089 |
| Bio databases IDs | |
| Aliases | chromodomain helicase DNA binding protein 1-like |
| Synonyms | 4432404A22Rik, ALC1, CHDL, chromodomain helicase DNA binding protein 1-like, LOC101060601, Snf2p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chd1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- macrodomain superfamily
- DEAD/DEAH box helicase
- protein binding activity, bridging
- SNF2-related domain
- helicase superfamily c-terminal domain
- chromatin binding
- enzyme
- protein binding
- DNA dependent ATPase
- ATPase
- Helicase conserved C-terminal domain
- DNA helicase
- AAA domain
- macro domain
- binding protein
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- Class II histone deacetylase complex subunits 2 and 3
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diffuse large B-cell lymphoma
- neoplasia
- lymphatic neoplasia
- gastric adenocarcinoma
- gastric epithelial cancer
- thymoma
- epithelial neoplasia
- metastasis
- liver cancer
- epithelial cancer
role in cell
- apoptosis
- expression in
- proliferation
- survival
- migration
- killing
- accessibility
- retention in
- DNA damage response
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chd1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- chromatin remodeling
- DNA duplex unwinding
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- nucleotide binding
- ATP binding
- DNA helicase activity
- protein binding
- nucleosome binding