Nos1 Gene Summary [Mouse]
Enables nitric-oxide synthase activity. Involved in several processes, including nitric oxide biosynthetic process; positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and positive regulation of the force of heart contraction. Acts upstream of or within several processes, including peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; and regulation of metal ion transport. Located in several cellular components, including T-tubule; Z disc; and sarcoplasmic reticulum membrane. Is active in calyx of Held. Colocalizes with caveola. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study achalasia and hypertrophic pyloric stenosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nos1 |
| Official Name | nitric oxide synthase 1, neuronal [Source:MGI Symbol;Acc:MGI:97360] |
| Ensembl ID | ENSMUSG00000029361 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase 1, neuronal |
| Synonyms | 2310005C01RIK, bNOS, IHPS1, iNOS, NADPH-d/NOS1, NC-NOS, Neuronal no synthase, nitric oxide synthase 1, nitric oxide synthase 1, neuronal, Nitric oxide synthetase, N-NOS, nNOS-2, NO, NOS, NOS-I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nos1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- FAD binding domain
- Nitric oxide synthase, oxygenase domain
- phosphoprotein binding
- transcription factor binding
- enzyme
- cadmium ion binding
- identical protein binding
- NADPH-dependent FMN reductase
- NOS_oxygenase
- NADPH binding
- zinc ion binding
- NADP binding
- FMN binding
- ion channel binding
- sulfite reductase [NADPH] flavoprotein, alpha-component
- oxygenase domain
- calcium-dependent protein binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- flavin adenine dinucleotide binding
- calmodulin binding
- nitric-oxide synthase
- enzyme binding
- canonical PDZ domain
- flavodoxin
- heme binding domain
- sodium channel regulator
- protein binding
- heme binding
- PDZ domain
- calcium channel regulator
- amino acid binding
- nitrogenous group transferase
- ATPase binding
- reductase domain
- binding protein
- hinge domain
- cpPDZ_Deg_HtrA-like
- Oxidoreductase NAD-binding domain
Pathways
Biological processes and signaling networks where the Nos1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Mitochondrial Dysfunction
- nNOS Signaling in Skeletal Muscle Cells
- Opioid Signaling Pathway
- Phagosome Maturation
- Sertoli Cell-Sertoli Cell Junction Signaling
- Small Cell Lung Cancer Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- heart failure
- systemic lupus erythematosus
- fibrosis
- neuroticism
- schizophrenia
- sedation
- insomnia
- Alzheimer disease
- major depression
role in cell
- migration
- expression in
- phosphorylation in
- proliferation
- binding in
- cell death
- accumulation in
- apoptosis
- colony formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- synaptic plasma membrane fractions
- nuclear fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- insoluble fractions
- glutaminergic synapse
- cytoskeleton
- organelle
- cell periphery
- somatodendritic region
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- Mitochondria
- costameres
- cytoplasmic matrix
- cytosol
- microsome
- postsynaptic membrane
- caveolae
- mitochondrial outer membrane
- nucleoplasm
- nuclear envelope
- synaptic vesicles
- neurites
- nerve ending
- synaptosomes
- synapse
- photoreceptor inner segments
- sarcolemma
- Z line
- myotendinous junctions
- azurophil granules
- transverse tubules
- secretory granules
- membrane rafts
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nos1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of guanylate cyclase activity
- xenobiotic catabolic process
- vasodilation
- negative regulation of potassium ion transport
- positive regulation of transcription from RNA polymerase II promoter
- striated muscle contraction
- negative regulation of hydrolase activity
- response to heat
- response to hypoxia
- positive regulation of transcription, DNA-dependent
- multicellular organismal response to stress
- negative regulation of calcium ion transport
- positive regulation of peptidyl-serine phosphorylation
- peptidyl-cysteine S-nitrosylation
- nitric oxide mediated signal transduction
- myoblast fusion
- negative regulation of blood pressure
- cell redox homeostasis
- response to hormone stimulus
- regulation of ryanodine-sensitive calcium-release channel activity
- arginine catabolic process
- regulation of sodium ion transport
- cellular response to growth factor stimulus
- negative regulation of calcium ion transport into cytosol
- response to lipopolysaccharide
- nitric oxide biosynthetic process
- regulation of cardiac muscle contraction by calcium ion signaling
- regulation of cardiac muscle contraction
- negative regulation of serotonin uptake
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- sarcoplasmic reticulum
- synapse
- plasma membrane
- nucleoplasm
- nucleus
- cytoskeleton
- perinuclear region of cytoplasm
- cytoplasm
- sarcolemma
- membrane raft
- mitochondrion
- dendritic spine
- cytosol
- macromolecular complex
- photoreceptor inner segment
- cell periphery
Molecular Function
What the gene product does at the molecular level
- FMN binding
- calcium-dependent protein binding
- calcium channel regulator activity
- ion channel binding
- heme binding
- sodium channel regulator activity
- scaffold protein binding
- arginine binding
- tetrahydrobiopterin binding
- calmodulin binding
- NADP binding
- protein binding
- nitric-oxide synthase activity
- flavin adenine dinucleotide binding
- cadmium ion binding