Chek2 Gene Summary [Mouse]
Enables protein kinase activity. Acts upstream of or within several processes, including cellular response to gamma radiation; signal transduction by p53 class mediator; and thymocyte apoptotic process. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chek2 |
| Official Name | checkpoint kinase 2 [Source:MGI Symbol;Acc:MGI:1355321] |
| Ensembl ID | ENSMUSG00000029521 |
| Bio databases IDs | |
| Aliases | checkpoint kinase 2 |
| Synonyms | CDS1, Check2, checkpoint kinase 2, CHK2, hCds1, HUCDS1, LFS2, PP1425, RAD53, TPDS4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chek2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- SQ/TQ cluster domain
- nuclear localization sequence
- protein binding
- Protein kinase domain
- identical protein binding
- phosphorylation site
- forkhead associated (FHA) domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ATP-binding pocket
- kinase domain
- Protein Kinases, catalytic domain
- FHA domain
- serine/threonine catalytic domain
- protein homodimerization
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Chek2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- ATM Signaling
- Cell Cycle Control of Chromosomal Replication
- Cell Cycle: G2/M DNA Damage Checkpoint Regulation
- DNA damage-induced 14-3-3σ Signaling
- Hereditary Breast Cancer Signaling
- Mitotic Roles of Polo-Like Kinase
- Molecular Mechanisms of Cancer
- p53 Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glaucoma
- open-angle glaucoma
- essential hypertension
- pancreatic neoplasia
- epithelial neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
role in cell
- expression in
- proliferation
- apoptosis
- growth
- activation in
- phosphorylation in
- production in
- cell death
- survival
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- mother centriole
- tax speckled structure
- Cytoplasm
- centrosome
- Golgi Apparatus
- midbody
- cytosol
- nuclear foci
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chek2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- replicative senescence
- protein catabolic process
- signal transduction in response to DNA damage
- regulation of protein catabolic process
- regulation of transcription, DNA-dependent
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- protein autophosphorylation
- DNA damage response, signal transduction resulting in induction of apoptosis
- response to DNA damage stimulus
- protein phosphorylation
- double-strand break repair
- cell division
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- DNA damage checkpoint
- cellular response to gamma radiation
- G2/M transition of mitotic cell cycle
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
- positive regulation of transcription, DNA-dependent
- thymocyte apoptotic process
- regulation of autophagic vacuole assembly
- intra-S DNA damage checkpoint
- protein stabilization
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- PML body
- cytoplasm
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- protein homodimerization activity
- metal ion binding
- protein serine/threonine kinase activity