Mttp

Enables cholesterol transfer activity; phosphatidylethanolamine transfer activity; and triglyceride transfer activity. Involved in circadian rhythm. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein transport; and low-density lipoprotein particle remodeling. Located in endoplasmic reticulum. Is expressed in several structures, including gut; liver; placenta; septum transversum hepatic component; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; metabolic dysfunction-associated steatotic liver disease; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mttp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Mttp gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mttp gene, providing context for its role in the cell.