Cth Gene Summary [Mouse]
Enables L-cystine L-cysteine-lyase (deaminating) and cystathionine gamma-lyase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and protein sulfhydration. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of apoptotic signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; ear; and genitourinary system. Used to study cystathioninuria. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cth |
| Official Name | cystathionase (cystathionine gamma-lyase) [Source:MGI Symbol;Acc:MGI:1339968] |
| Ensembl ID | ENSMUSG00000028179 |
| Bio databases IDs | |
| Aliases | cystathionase (cystathionine gamma-lyase) |
| Synonyms | 0610010I13Rik, CGL, CSE, Cys3, CYSTATHIONASE, Cystathione Gamma Lyase, Cystathione γ Lyase, Cystathionine Gamma-Lyase, Cystathionine γ-Lyase, LOC103691744, MGC28655 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cth often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cystathionine gamma-lyase
- O-succinylhomoserine sulfhydrylase
- carbon-sulfur lyase
- enzyme
- cystathionine beta-lyase, eukaryotic
- protein binding
- O-succinylhomoserine (thiol)-lyase
- identical protein binding
- Cys/Met metabolism PLP-dependent enzyme
- cystathionine beta-lyase, bacterial
- pyridoxal phosphate binding
- OAH/OAS sulfhydrylase
- AAT_I
- methionine gamma-lyase
Pathways
Biological processes and signaling networks where the Cth gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- non-insulin-dependent diabetes mellitus
- hypertension
- organismal death
- insulin-dependent diabetes mellitus
- cystathioninuria
- diabetes mellitus
- liver cancer
- Alzheimer disease
role in cell
- quantity
- expression in
- growth
- cell death
- cell viability
- chemotaxis
- proliferation
- apoptosis
- phosphorylation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cth gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hydrogen sulfide biosynthetic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cysteine metabolic process
- protein sulfhydration
- protein homotetramerization
- protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
- endoplasmic reticulum unfolded protein response
- lipid metabolic process
- cysteine biosynthetic process
- cysteine biosynthetic process via cystathionine
- transsulfuration
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- calmodulin binding
- identical protein binding
- protein binding
- homocysteine desulfhydrase activity
- L-cystine L-cysteine-lyase (deaminating)
- L-cysteine desulfhydrase activity
- cystathionine gamma-lyase activity