ERP44 Gene Summary [Human]
This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]
Details
| Type | Protein Coding |
| Official Symbol | ERP44 |
| Official Name | endoplasmic reticulum protein 44 [Source:HGNC Symbol;Acc:HGNC:18311] |
| Ensembl ID | ENSG00000023318 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum protein 44, protein disulfide isomerase family A, member 10 |
| Synonyms | 1110001E24Rik, AI849526, AL033348, BWK4, endoplasmic reticulum protein 44, Kiaa0573, PDIA10, TXNDC4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ERP44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- thioredoxin-like domain
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ocular sarcoidosis
- preeclampsia
- idiopathic scoliosis
- cystic kidney disease
role in cell
- phagocytosis
- phagocytosis by
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- secretory granule lumen
- cell surface
- Extracellular Space
- Nucleus
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ERP44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein metabolic process
- cell redox homeostasis
- protein folding
- response to unfolded protein
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- specific granule lumen
- endoplasmic reticulum-Golgi intermediate compartment
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide isomerase activity