Lamc1 Gene Summary [Mouse]
Enables glycosphingolipid binding activity. Involved in several processes, including hair cell differentiation; hair follicle cell proliferation; and hair follicle morphogenesis. Acts upstream of or within neuron projection development. Located in basement membrane. Part of laminin-10 complex. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lamc1 |
| Official Name | laminin, gamma 1 [Source:MGI Symbol;Acc:MGI:99914] |
| Ensembl ID | ENSMUSG00000026478 |
| Bio databases IDs | |
| Aliases | laminin, gamma 1 |
| Synonyms | B2e, LAMB2, LAMININ B2, laminin, gamma 1, laminin subunit gamma 1, laminin subunit γ 1, laminin, γ 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lamc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- Laminin B (Domain IV)
- nidogen binding domain
- EGF_CA
- Laminin Domain I
- Laminin-type epidermal growth factor-like domai
- Tropomyosin
- Myosin-like coiled-coil protein
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- Apolipophorin-III precursor (apoLp-III)
- SPEC
- Crescentin protein
- Laminin N-terminal (Domain VI)
- TPR/MLP1/MLP2-like protein
- sphingolipid binding
- Giardia variant-specific surface protein
- lipid binding
- Tropomyosin like
- PspA/IM30 family
- LN domain
- extracellular matrix structural constituent
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
- Methyl-accepting chemotaxis protein (MCP), signaling domain
- Helical region found in SNAREs
- SNARE motif
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lamc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- hypertriglyceridemia
- prostatic carcinoma
- prostate cancer
- neurodegeneration
- Fuchs endothelial dystrophy
- ischemic stroke
role in cell
- activation in
- differentiation
- proliferation
- expression in
- migration
- formation
- anchorage
- adhesion
- growth
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- endoplasmic reticulum lumen
- basal membrane
- nodes of Ranvier
- neuromuscular junctions
- synapse
- extracellular matrix
- basal lamina
- axon terminals
- plasma
- basement membrane
- endothelial basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lamc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- hemidesmosome assembly
- endoderm development
- extracellular matrix disassembly
- cell adhesion
- positive regulation of cell adhesion
- substrate adhesion-dependent cell spreading
- positive regulation of epithelial cell proliferation
- cell migration
- positive regulation of integrin-mediated signaling pathway
- positive regulation of muscle cell differentiation
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- laminin-11 complex
- basement membrane
- extracellular space
- extracellular vesicular exosome
- laminin-1 complex
- extracellular region
- laminin-10 complex
Molecular Function
What the gene product does at the molecular level
- extracellular matrix constituent conferring elasticity
- extracellular matrix structural constituent