Invs Gene Summary [Mouse]
Predicted to enable calmodulin binding activity. Acts upstream of or within several processes, including left/right pattern formation; protein localization to ciliary inversin compartment; and protein phosphorylation. Located in ciliary base and ciliary inversin compartment. Is expressed in several structures, including adrenal gland; brain; gut gland; hemolymphoid system; and skeletal musculature. Used to study nephronophthisis 2 and tetralogy of Fallot. Human ortholog(s) of this gene implicated in hypertension and nephronophthisis 2. Orthologous to human INVS (inversin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Invs |
| Official Name | inversin [Source:MGI Symbol;Acc:MGI:1335082] |
| Ensembl ID | ENSMUSG00000028344 |
| Bio databases IDs | |
| Aliases | inversin |
| Synonyms | INV, inversin, NPH2, NPHP2, RGD1563359 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Invs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Facioscapulohumeral muscular dystrophy candidate 2
- Neuroendocrine-specific golgi protein P55 (NESP55)
- transcription regulator
- Ankyrin repeats (many copies)
- IQ (isoleucine-glutamine) motif containing G and D (IQCG and IQCD)
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- nephronophthisis type 2
- nephronophthisis
- COVID-19
- urological disorder
- cystic kidney disease
- ocular sarcoidosis
- situs inversus totalis
- hereditary disorder
- chickenpox
role in cell
- apoptosis
- mitosis
- distortion in
- binding in
- misalignment
- misalignment in
- dimerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- motile primary cilium
- cytoskeleton
- Cytoplasm
- cilia
- perinuclear region
- Plasma Membrane
- basal bodies
- centriole
- cytosol
- primary cilia
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Invs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- spindle
- microtubule
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding