Krt5 Gene Summary [Mouse]
Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Involved in several processes, including intermediate filament polymerization; regulation of cell migration; and response to mechanical stimulus. Located in cytoplasm; keratin filament; and plasma membrane. Is active in cornified envelope. Is expressed in several structures, including alimentary system; epithelium; genitourinary system; integumental system; and sensory organ. Used to study epidermolysis bullosa simplex Dowling-Meara type. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt5 |
| Official Name | keratin 5 [Source:MGI Symbol;Acc:MGI:96702] |
| Ensembl ID | ENSMUSG00000061527 |
| Bio databases IDs | |
| Aliases | keratin 5 |
| Synonyms | 3300001P10Rik, CK5, Cytokeratin5, DDD, DDD1, EBS1, EBS2, EBS2A, EBS2B, EBS2C, EBS2D, EBS2E, EBS2F, K5, Keratin 5, Krt2-5, KRT5A, Sak57, Tfip8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
- Keratin type II head
- head domain
Pathways
Biological processes and signaling networks where the Krt5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- chronic sinusitis
- psoriasis
- atopic dermatitis
- epithelial cancer
- idiopathic pulmonary fibrosis
- autosomal recessive generalized intermediate epidermolysis bullosa simplex type 2D
- localized epidermolysis bullosa simplex 2C
- autosomal recessive generalized severe epidermolysis bullosa simplex type 2D
- skin neoplasm
role in cell
- transactivation in
- migration
- size
- localization
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cornified envelope
- Plasma Membrane
- intermediate filaments
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- epidermis development
- regulation of cell migration
- keratinization
- intermediate filament organization
- response to mechanical stimulus
- intermediate filament polymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- keratin filament
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton