Tal2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within midbrain development; post-embryonic development; and thalamus development. Is expressed in several structures, including central nervous system; future midbrain; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia and adult T-cell leukemia/lymphoma. Orthologous to human TAL2 (TAL bHLH transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tal2 |
| Official Name | T cell acute lymphocytic leukemia 2 [Source:MGI Symbol;Acc:MGI:99540] |
| Ensembl ID | ENSMUSG00000028417 |
| Bio databases IDs | |
| Aliases | T cell acute lymphocytic leukemia 2 |
| Synonyms | bHLHa19, LOC681608, Tail2, TAL bHLH transcription factor 2, T cell acute lymphocytic leukaemia 2, T cell acute lymphocytic leukemia 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tal2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- helix-loop-helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- DNA binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tal2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- midbrain development
- post-embryonic development
- thalamus development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity