Tesk1 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and protein serine/threonine kinase activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay; podocyte cell migration; and regulation of actin cytoskeleton organization. Predicted to be located in centrosome; cytoplasmic vesicle; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cochlea and tooth. Orthologous to human TESK1 (testis associated actin remodelling kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tesk1 |
| Official Name | testis specific protein kinase 1 [Source:MGI Symbol;Acc:MGI:1201675] |
| Ensembl ID | ENSMUSG00000028458 |
| Bio databases IDs | |
| Aliases | testis specific protein kinase 1 |
| Synonyms | p36-MBPK, testis associated actin remodelling kinase 1, testis specific protein kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tesk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- conserved domain
- kinase domain
- protein serine/threonine kinase inhibitor
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Tesk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- migration
- formation
- assembly
- ciliogenesis in
- clustering in
- organization
- outgrowth
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- vesicles
- centrosome
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tesk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- regulation of protein localization
- spermatogenesis
- positive regulation of substrate adhesion-dependent cell spreading
- negative regulation of phosphorylation
- regulation of actin cytoskeleton organization
- establishment of vesicle localization
- positive regulation of stress fiber assembly
- positive regulation of protein phosphorylation
- negative regulation of protein serine/threonine kinase activity
- actin cytoskeleton organization
- negative regulation of protein autophosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- cytoplasmic vesicle
- cytosol
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein tyrosine kinase activity
- protein binding
- protein serine/threonine/tyrosine kinase activity
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity