Cfl1

Enables actin filament binding activity and signaling receptor binding activity. Involved in cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and protein phosphorylation. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including early conceptus; genitourinary system; immune system; nervous system; and skin. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cfl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfl1 gene, providing context for its role in the cell.