Spry2 Gene Summary [Mouse]
Enables ubiquitin-protein transferase inhibitor activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; epithelium; future brain; and genitourinary system. Used to study achalasia; ciliopathy; intestinal pseudo-obstruction; and prostate cancer. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spry2 |
| Official Name | sprouty RTK signaling antagonist 2 [Source:MGI Symbol;Acc:MGI:1345138] |
| Ensembl ID | ENSMUSG00000022114 |
| Bio databases IDs | |
| Aliases | sprouty RTK signaling antagonist 2 |
| Synonyms | hSPRY2, IGAN3, sprouty2, sprouty RTK signaling antagonist 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spry2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein serine/threonine kinase inhibitor
- cCbl binding domain
- protein kinase binding
- enzyme inhibitor activity
- protein binding
- enzyme regulator activity
- endophilin binding domain
- zDHHC ankyrin repeat binding domain
- cysteine rich domain
- Sprouty protein (Spry)
- phosphorylation site
Pathways
Biological processes and signaling networks where the Spry2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- benign neoplasia
- neoplasia
- organismal death
- Crohn disease
- susceptibility to IgA nephropathy type 3
- bipolar disorder
- ulcerative colitis
- schizophrenia
- allergic asthma
role in cell
- phosphorylation in
- expression in
- production in
- growth
- apoptosis
- invasion
- cell viability
- invasion by
- migration
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- actin cytoskeleton
- Nucleus
- endosomes
- microtubules
- midbody
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spry2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of angiogenesis
- negative regulation of MAP kinase activity
- negative regulation of cell proliferation
- positive regulation of epidermal growth factor receptor signaling pathway
- bud elongation involved in lung branching
- fibroblast growth factor receptor signaling pathway
- organ development
- sensory perception of sound
- negative regulation of vascular endothelial growth factor signaling pathway
- negative regulation of nerve growth factor receptor signaling pathway
- negative regulation of epithelial to mesenchymal transition
- negative regulation of Ras protein signal transduction
- negative regulation of protein ubiquitination
- positive regulation of peptidyl-serine phosphorylation
- lung growth
- ERK1 and ERK2 cascade
- establishment of mitotic spindle orientation
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of apoptotic process
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of gene expression
- positive regulation of ERK1 and ERK2 cascade
- inner ear morphogenesis
- cell fate commitment
- cellular response to vascular endothelial growth factor stimulus
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of protein kinase B signaling cascade
- negative regulation of cell projection organization
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- cytoskeleton
- membrane
- actin cytoskeleton
- cytosol
- ruffle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein serine/threonine kinase inhibitor activity
- protein serine/threonine kinase activator activity
- protein binding
- ubiquitin-protein ligase inhibitor activity