Abcg1 Gene Summary [Mouse]
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Abcg1 |
| Official Name | ATP binding cassette subfamily G member 1 [Source:MGI Symbol;Acc:MGI:107704] |
| Ensembl ID | ENSMUSG00000024030 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily G member 1 |
| Synonyms | ABC8, ATP binding cassette subfamily G member 1, White, WHITE1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC-2 type transporter
- ATPase activity, coupled to transmembrane movement of substances
- FeS assembly ATPase SufC
- The Eye Pigment Precursor Transporter (EPP) Family protein
- ADP binding
- phosphonate ABC transporter, ATP-binding protein
- ATP binding
- walker type A motif
- protein binding
- nitrate transport ATP-binding subunits C and D
- urea ABC transporter, ATP-binding protein UrtE
- heme ABC exporter, ATP-binding protein CcmA
- lipid transporter
- cobalt transport protein ATP-binding subunit
- phosphatidylcholine transporter
- energy-coupling factor transporter ATPase
- protein homodimerization
- toxin transporter
- ABC transporter
- thiamine ABC transporter, ATP-binding protein
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- obesity
- sporadic amyotrophic lateral sclerosis
- endometriosis
- organismal death
- diabetic nephropathy
- insulin-dependent diabetes mellitus
- bleeding
- coronary stenosis
- chronic granulomatous disease
role in cell
- expression in
- apoptosis
- accumulation in
- phosphorylation in
- proliferation
- differentiation
- dysfunction
- quantity
- degeneration
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- Golgi Apparatus
- Mitochondria
- apical cell surfaces
- endoplasmic reticulum membrane
- plasma membrane extracellular face
- nucleoplasm
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- amyloid precursor protein catabolic process
- transmembrane transport
- high-density lipoprotein particle remodeling
- low-density lipoprotein particle remodeling
- cholesterol metabolic process
- positive regulation of cholesterol biosynthetic process
- cholesterol homeostasis
- phospholipid homeostasis
- regulation of cholesterol metabolic process
- reverse cholesterol transport
- positive regulation of cholesterol efflux
- lipid translocation
- intracellular cholesterol transport
- cellular response to high density lipoprotein particle stimulus
- negative regulation of macrophage derived foam cell differentiation
- cholesterol efflux
- response to lipid
- negative regulation of cholesterol storage
- positive regulation of protein secretion
- phospholipid efflux
- glycoprotein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endosome
- mitochondrion
- external side of plasma membrane
- recycling endosome
- Golgi membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- sterol-transporting ATPase activity
- protein binding
- protein homodimerization activity
- cholesterol binding
- protein heterodimerization activity
- ADP binding
- phospholipid binding
- toxin transporter activity