Wdr5 Gene Summary [Mouse]
Enables histone H3K4 methyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within peptidyl-lysine methylation; positive regulation of gluconeogenesis; and skeletal system development. Located in nucleus. Part of ATAC complex. Is expressed in several structures, including cerebral cortex; colon; genitourinary system; hemolymphoid system gland; and vault of skull. Orthologous to human WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Wdr5 |
| Official Name | WD repeat domain 5 [Source:MGI Symbol;Acc:MGI:2155884] |
| Ensembl ID | ENSMUSG00000026917 |
| Bio databases IDs | |
| Aliases | WD repeat domain 5 |
| Synonyms | 2410008O07Rik, Big, BIG-3, CFAP89, LOC100912075, LOC108348033, SWD3, WD repeat domain 5, WDRP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- histone binding
- transcription regulator
- histone lysine N-methyltransferase activity (H3-K4 specific)
- WD40 repeats
- protein binding activity, bridging
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- prostate cancer
- organismal death
- congenital heart disease
- pulmonary hypertension
role in cell
- apoptosis
- formation in
- accumulation in
- degradation in
- binding in
- expression in
- quantity
- activation in
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- intracellular space
- midbody
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- positive regulation of gene expression, epigenetic
- regulation of embryonic development
- regulation of tubulin deacetylation
- regulation of transcription, DNA-dependent
- positive regulation of gluconeogenesis
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- skeletal system development
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- mitotic spindle
- histone methyltransferase complex
- NSL complex
- histone acetyltransferase complex
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- histone methyltransferase activity (H3-K4 specific)
- protein binding
- histone binding
- methylated histone residue binding